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KMID : 0364820180540020152
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Korean Journal of Microbiology
2018 Volume.54 No. 2 p.152 ~ p.154
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Draft genome sequence of lytic bacteriophage KP1 infecting bacterial pathogen Klebsiella pneumoniae
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Kim Young-Ju
Bang In-A
Yeon Young-Eun
Park Joon-Young
Han Beom-Ku
Kim Hyun-Il
Kim Dong-Hyuk
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Abstract
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Klebsiella pneumoniae is a Gram-negative, rod-shape bacteriumcausing disease in human and animal lungs. K. pneumoniae hasbeen often found to gain antimicrobial resistance, thus it hasbeen difficult to treat K. pneumoniae infection with antibiotics. Forsuch infection, bacteriophage can provide an alternativeapproach for pathogenic bacterial infection with antimicrobialresistance, because of its sensitivity and specificity to the hostbacteria. Bacteriophage KP1 was isolated in sewage andshowed specific infectivity to K. pneumoniae. Here, we reportthe draft genome sequence of Klebsiella pneumoniae phageKP1. The draft genome of KP1 is 167,989 bp long, and the G +C content is 39.6%. The genome has 295 predicted ORFs and 14tRNA genes. In addition, it encodes various enzymes whichinvolve in lysis of the host cell such as lysozyme and holin.
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KEYWORD
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Klebsiella pneumoniae, bacteriophage, draft genome sequence, Illumina Hiseq
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